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This makes your bones weak and increases your risk for bone fractures or breaks. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh. For women with osteoporosis after menopause at high risk for fracture. Biosimilars usually cost less than brand-name drugs. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. Yes, if recommended by your doctor, you can stop taking Prolia. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Prolias manufacturer also provides some self-injection instructions, as well as a video to show you how to inject Prolia. If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. Youll get Prolia injections from a healthcare professional once every 6 months. For a basic overview of Prolia, including details about its uses, see this article. But certain choices and habits accelerate the process. It works with your immune system to help prevent bone loss. pain in bones and muscles, including back, arm, and leg pain, pain or swelling in the thigh or groin area. They can give you more details about this possible side effect and suggest ways to manage it. Both are prescription medicines. Your risk for infection with Prolia may be higher if you have a weakened immune system. Prolia has active ingredients of denosumab. Ask your doctor about the pros and cons of using Prolia. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. that's no different than scheduling a visit to the dentist twice a year. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Prolia may lower the calcium levels in your blood. Prolia should not be used during pregnancy. Prolia may be used off-label for RA, if you have a high risk for bone fractures. Your risk for some health conditions increases when you are postmenopausal. Prolia side effects: What you should know - Medical Prolia isnt known to cause any harmful interactions with alcohol. or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. For instance, if you have a health condition that causes excess calcium in Although both drugs are approved to treat similar conditions, they work in different ways. Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. These side effects may include: Its not known what percentage of people in clinical trials developed dental or jaw-related side effects. This is because your body doesnt make enough bone, or it loses bone faster than it makes new bone. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. 2023 eHealthMe.com. You should also talk with them if you have any serious side effects during Prolia treatment. If your doctor says this is safe for you, youll be shown how to inject the medication. But if you think youre having a medical emergency, call 911 or your local emergency number. Courtney Sullivan, Certified Yoga Instructor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. Prolia contains the active drug denosumab, while Tymlos contains the active drug abaloparatide. Prolia also has other uses, which are described in the next section below. What should I know about Prolia vs. Fosamax? Do not take this medicine with any of the following medications: This medicine may also interact with the following medications: This list may not describe all possible interactions. In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. Prolia and Forteo are both used to treat osteoporosis. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. Your doctor can give you more information about the risks and benefits and how Reclast compares with Prolia. Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. Do any of yall know? Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Do not become pregnant while taking this medicine or for 5 months after stopping it. These factors include what your insurance plan covers. But its not clear whether this side effect occurred in clinical studies. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. Osteopenia If youre concerned about hair loss with Prolia, talk with your doctor. MEDICATION GUIDE Prolia (PR-lee-a) (denosumab) WebIn many individuals, calcium supplements are better absorbed when taken with food. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Prolia is usually given once every 6 months. The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. What Health Changes Should You Expect Postmenopause? Prolia can cause both mild and serious side effects. supplements If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia. (Vitamin D helps your body absorb calcium.) So, if you want to stop taking Prolia, talk with your doctor. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. Other drugs that have the same active ingredients (e.g. in your skin, lower stomach area (abdomen), bladder, or ear may happen. As mentioned above, Prolia contains the active drug denosumab. If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. Learn how to slow it down and fortify your body against it. You can use the study as a second opinion to make health care decisions. Follow your doctor's instructions. Some people who take Prolia develop severe bone, joint, or muscle pain. Advertising on our site helps support our mission. They may give you tips on managing a body weight thats healthy for you. Osteoporosis is a condition that causes your bones to become thin and weak. It is important for you to practice good mouth care during treatment with Prolia. Do not share this medicine with others. * Sex and gender exist on spectrums. If you have a low calcium level, you should not take Prolia. Do not use denosumab if you are pregnant. The list below may not include all possible serious side effects of the drug. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. Tell your doctor if you become pregnant. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments This information is intended only for U.S. healthcare professionals. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. And you should continue using birth control for at least 5 months after stopping Prolia. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. Learn how to increase or maintain bone density here. Ask your doctor about your own risk. Denosumab is contraindicated in women with hypocalcaemia. Talk to your health care professional or pharmacist for more information. Continue reading. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Low blood calcium level. You may also want to do some research on your own. Q: Does AlgaePlus Increase Bone Mass? High cholesterol itself doesnt cause any symptoms. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. To learn more about this, see the How is Prolia administered? section below. Serious infections may occur during treatment with Prolia. Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Yoga is an excellent way to manage symptoms of osteoporosis. The fractures may require surgeries, take several months to heal, or both. Can diet help improve depression symptoms? What osteoporosis medications are there, and what side effects do they have? Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. Take good care of your teeth and gums while you receive Prolia. But it can increase your risk of serious health problems, such as heart attack. Last medically reviewed on November 29, 2022. But its believed that these side effects are rare. Youll receive 60 mg/mL of Prolia once every 6 months. (BMD is a measurement of the amount of minerals such as calcium in your bones.) Theyll need to confirm that you arent pregnant. These medications have different active ingredients and they belong to different groups of drugs. But if they become bothersome, talk with your doctor or pharmacist. Prolia and Evenity are both biologic medications, but Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. Osteoporosis Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. may occur. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. Prolia Subcutaneous: Uses, Side Effects, Interactions, Pictures With osteopenia, your bone mineral density (BMD) is lower than usual. People need calcium for bone health and other functions. * Sex and gender exist on spectrums. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture Your risk of bone fractures can increase when you stop, skip or delay using Prolia. Kidney problems. WebDrug interactions are reported among people who take Prolia and Calcium. Women going through menopause have a higher risk of developing osteoporosis. It is often used in osteoporosis. They may be able to help you identify the cause. Talk with your doctor about the risks of using this drug during pregnancy. Prolia solution is available in one strength: 60 milligrams per milliliter (mg/mL). Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) Constipation was also reported as a side effect in females using Prolia for osteoporosis. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ada.org/en/member-center/oral-health-topics/osteoporosis-medications, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125320s210lbl.pdf, New clues to slow aging? If you have low blood calcium, it may get worse during treatment. Prolia (denosumab) | Dosing You should also take calcium and vitamin D supplements while being But if youre planning to have surgery, you may need to take a break have happened in people who take Prolia. It can have some side effects, but these may depend on who uses it. Prolia may lower the level of calcium in your blood. These include osteonecrosis of the jawbone. Tingling wasnt specifically reported as a side effect of Prolia in clinical trials. Stopping Prolia doesnt cause withdrawal symptoms. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. Prolia contains the same medicine as XGEVA (denosumab). They also include any added costs of the drug being given by a healthcare professional. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. Results may vary. Calcium and calcium supplements: Achieving the right We comply with the HONcode standard for trustworthy health information. Its recommended that calcium and vitamin D supplements be taken Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. (2022). These treatments may include acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. All subjects in the clinical trials of Prolia received 800mg of calcium and For more information on this side effect, see Side effect specifics below. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. Based on your dental history, your doctor can discuss with you the risks of using Prolia. They may also have you see your dentist. They can also happen if you have certain conditions or if you take certain medications. NOTE: This medicine is only for you. All rights reserved. you (To learn more, see the Side effect specifics section above.). Do not share this medicine with another person, even if they have the same symptoms you have. * For more information about this side effect, see Side effect specifics below. Mild side effects can occur with Prolia use. If you have a male* sexual partner, they should use birth control during this time as well. If you have low calcium levels, you should not take Prolia. (A placebo is a treatment with no active drug.). If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. Prolia Injection (Denosumab): Uses & Side Effects Youll receive Prolia doses from a healthcare professional. They need to know if you have any of these conditions: This medicine is for injection under the skin. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. This medicine may cause jaw bone problems (osteonecrosis). But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. Be sure to read this information carefully each time. Talk with them about your health and any concerns you have about Prolia and its effects. The drug could cause your calcium level to drop too low. It may also be higher if you have dental work done while youre taking Prolia. This increases your risk for bone fractures. It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. DENOSUMAB (den oh sue mab) slows bone breakdown. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or; if you are pregnant. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed.